Match events
Minute by minute- 10' Yellow card: Amine Adli Bayer Leverkusen
- 42'1–0 Goal: Moussa DiabyAssist: Florian Wirtz Bayer Leverkusen
- 44' Yellow card: Robert Andrich Bayer Leverkusen
- 45' Substitution: Sergio CanalesOff: William Carvalho Real Betis
- 45' Substitution: Álex MorenoOff: Juan Miranda Real Betis
- Half-time 1–0
- 52'2–0 Goal: Moussa Diaby Bayer Leverkusen
- 59' Substitution: Rodri SánchezOff: Aitor Ruibal Real Betis
- 69' Substitution: Exequiel PalaciosOff: Paulinho Bayer Leverkusen
- 72' Substitution: Willian JoséOff: Borja Iglesias Real Betis
- 77' Substitution: Nadiem AmiriOff: Amine Adli Bayer Leverkusen
- 77' Substitution: Daley SinkgravenOff: Piero Hincapié Bayer Leverkusen
- 79' Substitution: JuanmiOff: Joaquín Real Betis
- 86'3–0 Goal: Florian WirtzAssist: Moussa Diaby Bayer Leverkusen
- 88' Substitution: Odilon KossounouOff: Florian Wirtz Bayer Leverkusen
- 88' Substitution: Panagiotis RetsosOff: Jeremie Frimpong Bayer Leverkusen
- 90'4–0 Goal: Nadiem AmiriAssist: Moussa Diaby Bayer Leverkusen
- 90+3' Red card: Nabil Fekir Real Betis
- 90+3' Red card: Kerem Demirbay Bayer Leverkusen
Line-ups
Confirmed
Bayer Leverkusen4-4-24-2-3-1Real Betis
- 1 Hradecky
- 3377' Hincapié
- 12 Tapsoba
- 4 Tah
- 3088' Frimpong
- 19A2 Diaby
- 10 Demirbay
- 8 Andrich
- 769' Paulinho
- 27A88' Wirtz
- 3177' Adli
- 13 Silva
- 3345' Miranda
- 6 Ruiz
- 5 Bartra
- 19 Bellerín
- 1445' Carvalho
- 21 Rodríguez
- 2459' Ruibal
- 8 Fekir
- 1779' Joaquín
- 972' Iglesias
Bayer Leverkusen bench
- 3Panagiotis Retsos88'
- 6Odilon Kossounou88'
- 11Nadiem Amiri77'
- 22Daley Sinkgraven77'
- 25Exequiel Palacios69'
Real Betis bench
- 7Juanmi79'
- 15Álex Moreno45'
- 12Willian José72'
- 10Sergio Canales45'
- 28Rodri Sánchez59'